To put that into perspective, the typical dose of CBD oil users is somewhere in the range of 10 to 80 mgs per day, with slightly higher doses for therapeutic issues or “flare-ups”. As we can see, this study does not mimic the typical usage patterns of most CBD consumers. Like any health product though, you should be aware of potential adverse side effects and possible dangers of ingesting anything new into your body. That being said, there are many other medications and herbal supplements that may also cause liver damage in high quantities. So you need to be aware of the proper dosage for any health product you are taking to understand how much is too much.
CBD is actually derived from hemp and is a chemical compound called “cannabinoids” originally found in the cannabis plant. The key difference in hemp versus CBD is that CBD is made by extracting the oil and diluting it with a carrier oil. Carrier oils could be coconut, hemp seed oil, avocado, almond, etc.
While CBD has been used to treat a myriad of different health issues, it is likely not recommended to use CBD with the intention of reversing liver damage. After all, a 2019 study found high concentrations of CBD to actually cause liver damage. In some cases — such as fatty liver disease, inflammation, and alcohol liver disease — liver damage can be reversed. Reversal of these issues requires the patient to stop drinking and can even be reversed in as little as six weeks — depending on the cause and the issue.
If the liver tissue ceases working, it does not function properly and eventually gets smaller and can even lead to failure. The study involved the aforementioned Epidiolex — the FDA’s only approved CBD drug. Researchers found mice treated with the epilepsy drug were at an increased risk for liver toxicity, despite using the recommended dosage and adhering to safety recommendations on Epidiolex’s label. As it stands, the Food and Drug Administration has approved a drug called Epidiolex.
While you should not be concerned with liver damage for using CBD, that does not necessarily mean that there are no adverse side effects or dangers when consuming CBD. As stated above, the WHO regards CBD as generally safe and well tolerated by humans, but there are some precautions one should take, just like with any other health product.
If fibrosis has settled in, which means regular tissue has been replaced with scar tissue, the liver damage likely cannot be reversed. Cirrhosis is another medical issue that often cannot be reversed. As a result of cirrhosis, much of the liver’s tissue transforms to fibrosis, and affected scar tissue can form no legitimate function.
According to the University of Arkansas for Medical Science CBD gummies for sale study, the mice who received the highest concentrations of CBD experienced liver damage and eventually died. These “highest concentrations” equate to 200 milligrams of CBD for a human. This level of dosage for mice resulted in liver toxicity and ultimately, death.
Extremely high levels of CBD may have potential to cause liver damage and other mild side effects, similar to any other herbal or medical supplement. If you are taking any prescription medications, we advise that you speak with your doctor before consuming CBD. One point of concern that some may need to be cognizant of is that CBD may interact with certain prescription medications. Our liver has a group of enzymes called cytochrome P450, which breaks down specific drugs into smaller bits to allow our cells to absorb them better and eliminate them properly. Even though the effects have been shown to be minimal, CBD can inhibit the CYP450 system’s ability to metabolize certain pharmaceutical drugs.
CBD oil is legal in 30 states where medicinal and/or recreational marijuana is legal, according to Governing magazine. In other words, anyone taking CBD regularly and in higher doses might unwittingly find themselves on the road to liver disease. Lead study author Igor Koturbash, PhD, recently told the health siteNutra Ingredients USA that the risk of liver damage from CBD is a nasty side effect printed in black and white on GW Pharma’s Epidiolex packaging.
About 10 percent of people taking CBD in studies had increases in liver enzymes, which would indicate possible liver damage, Welty said. This could mean that people taking anti-epilepsy drugs alongside CBD will need to adjust their dosage downward to avoid side effects, Welty noted. For example, epilepsy studies found that "there were very clearly increases in the blood levels of some other anti-epileptic drugs when people were on CBD," Welty said. There also are concerns about both the quality of CBD oil being produced and its potential side effects, the experts added.